A Pakistani injured polio worker is treated at a local hospital in Peshawar, Pakistan on Wednesday, Dec. 19, 2012. Gunmen shot dead a woman working on U.N.-backed polio vaccination efforts and her driver in northwestern Pakistan, officials said, just a day after similar attacks across the country killed several female polio workers. (AP Photo/Mohammad Sajjad)
A Pakistani injured polio worker is treated at a local hospital in Peshawar, Pakistan on Wednesday, Dec. 19, 2012. Gunmen shot dead a woman working on U.N.-backed polio vaccination efforts and her driver in northwestern Pakistan, officials said, just a day after similar attacks across the country killed several female polio workers. (AP Photo/Mohammad Sajjad)
A Pakistani injured polio worker is treated at a local hospital in Peshawar, Pakistan, Wednesday, Dec. 19, 2012. Gunmen shot dead a woman working on U.N.-backed polio vaccination efforts and her driver in northwestern Pakistan, officials said, just a day after similar attacks across the country killed several female polio workers. (AP Photo/Mohammad Sajjad)
A Pakistani polio worker administers polio drops to an infant in a Christian colony situated in the slums of Islamabad, Pakistan on Wednesday, Dec. 19, 2012 in Islamabad, Pakistan. Gunmen shot dead a woman working on U.N.-backed polio vaccination efforts and her driver in northwestern Pakistan, officials said, just a day after similar attacks across the country killed several female polio workers. (AP Photo/B.K. Bangash)
A Pakistani health worker marks an infant after immunization with anti-polio drops an infant in a Christian colony situated in the slums of Islamabad, Pakistan on Wednesday, Dec. 19, 2012 in Islamabad, Pakistan. Gunmen shot dead a woman working on U.N.-backed polio vaccination efforts and her driver in northwestern Pakistan, officials said, just a day after similar attacks across the country killed several female polio workers. (AP Photo/B.K. Bangash)
A Pakistani female polio worker administers polio drops to an infant in Christian colony situated in the slums of Islamabad, Pakistan on Wednesday, Dec. 19, 2012 in Islamabad, Pakistan. Gunmen shot dead a woman working on U.N.-backed polio vaccination efforts and her driver in northwestern Pakistan, officials said, just a day after similar attacks across the country killed several female polio workers. (AP Photo/B.K. Bangash)
PESHAWAR, Pakistan (AP) ? Gunmen shot dead a woman working on U.N.-backed polio vaccination efforts and her driver in northwestern Pakistan on Wednesday, officials said, raising to eight the number of people killed in the last 48 hours who were part of the immunization drive.
The attack on the woman was one of five that took place on polio workers in northwestern Pakistan on Wednesday. One male polio worker was critically wounded, while the others managed to escape unharmed.
The recent killings prompted the U.N.'s public health arm to suspend work on the vaccination drive in two of Pakistan's four provinces Wednesday, a major setback for a campaign that international health officials consider vital to contain the crippling disease but which Taliban insurgents say is a cover for espionage.
No group has claimed responsibility for the attacks. Suspicion has fallen on the Pakistani Taliban because of their virulent opposition to the polio campaign, but the group's spokesman, Ahsanullah Ahsan, denied responsibility in a telephone call to The Associated Press.
Pakistan is one of only three countries where polio is endemic. Prevention efforts have managed to reduce the number of cases in Pakistan by around 70 percent this year compared to 2011. But the recent violence threatens to reverse that progress.
Militants accuse health workers of acting as spies for the U.S. and claim the vaccine makes children sterile. Taliban commanders in the troubled northwest tribal region have also said vaccinations can't go forward until the U.S. stops drone strikes in the country.
Insurgent opposition to the campaign grew last year after it was revealed that a Pakistani doctor ran a fake vaccination program to help the CIA track down al-Qaida chief Osama bin Laden, who was hiding in the town of Abbottabad in the country's northwest.
The number of attacks this week on polio workers is unprecedented. They came as the government started a three-day vaccination drive Monday targeting high risk areas of the country, part of an effort to immunize millions of children under the age of five.
The deadliest of Wednesday's attacks occurred in the northwestern town of Charsadda, where the female polio worker and her driver were gunned down, said senior government official Syed Zafar Ali Shah. Gunmen attacked two other polio teams in Charsadda and one in the town of Nowshera, but no one was hurt in those attacks, he said.
Earlier in the day, gunmen shot a polio worker in the head in the city of Peshawar, wounding him critically, said Janbaz Afridi, a senior health official in surrounding Khyber Pakhtunkhwa province.
On Tuesday, gunmen killed five female polio workers ? three of them teenagers ? in a series of attacks in Karachi, the capital of southern Sindh province, and a village outside Peshawar. Two men who were working alongside the women were critically wounded in those attacks. A male polio worker was also shot to death in Karachi on Monday.
Maryam Yunus, a spokeswoman for the U.N. World Health Organization in Pakistan, said the group's polio staff have been pulled back from the field in Khyber Pakhtunkhwa and Sindh and asked to work from home until the vaccination campaign ends Wednesday.
Officials in Karachi temporarily suspended the vaccination campaign in the city after the shootings Tuesday, but the Khyber Pakhtunkhwa government plowed ahead, not wanting to be cowed by the violence.
Several dozen polio workers and human rights activists protested against the killings in Pakistan's capital, Islamabad, on Wednesday and demanded security for the field staff.
The Pakistani government and the U.N. have also condemned the attacks, saying they deprive Pakistan's most vulnerable populations ? specifically children ? of basic life-saving health interventions.
Polio usually infects children living in unsanitary conditions, attacks the nerves and can kill or paralyze. A total of 56 polio cases have been reported in Pakistan during 2012, down from 190 the previous year, according to the U.N. Most of the new cases in Pakistan are in the northwest, where the presence of militants makes it difficult to reach children.
Despite the obstacles, the government has teamed up with U.N. agencies to give oral polio drops to 34 million children under the age of five. Clerics and tribal elders have been recruited to support polio vaccinations in an attempt to open up areas previously inaccessible to health workers.
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Associated Press writer Rasool Dawar in Peshawar, Pakistan, contributed to this report.
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