Thursday, 22 November 2012

Breast Cancer Awareness: Staying In The Pink Of Health | Asian ...


By David Dickson | Editorials
November 22, 2012

David Tan takes a look at the annual Pink Ribbon campaign that aims to increase breast cancer awareness and raise funds for cancer research.


AsianScientist (Nov. 22, 2012) ? Unless you are a hermit living far from civilization, you would surely have come across a pink ribbon or two this past October.

As the pink glow of October?s breast cancer awareness campaign recedes, pundits are starting to assess the benefit of the pink movement.

The Breast Cancer Awareness Month campaign began in 1985 and the pink ribbon that now symbolizes the cause was first given out at a New York City race for breast cancer survivors in 1991. Since then, the trickle of pink into the public consciousness has grown into a flood each October.

At first glance, large-scale breast cancer awareness campaigns appear to be hitting all the right targets. After all, they have brought the issue to the fore, helping remove the stigma associated with cancer, as well as encouraging women to practice self-examination and attend regular check-ups. Campaigns also have significant psychological impact in offering support to breast cancer sufferers.

Show me the money

However, not everyone is convinced of the overall benefit. For starters, some critics feel the breast cancer awareness movement has grown to such a staggering scale that most of the funds raised are used to sustain the campaigns themselves instead of going toward cancer research.

For example, the Susan G. Komen foundation that initiated the pink ribbon movement in the first place, has recently come into the spotlight for only spending 15 percent or US$63 million of the money it raised in 2011 on research. The rest was spent on education, screening, and treatment, which while useful, divert resources from those trying to find solutions.

Others feel that the well-intentioned movement has been hijacked by companies seeking new opportunities. Indiscriminate use of the color pink or the pink ribbon to associate products with the breast cancer awareness campaign for commercial gain has become more widespread of late. So much so that Breast Cancer Action described the blatant profiteering as ?pinkwashing, ? a portmanteau of ?pink ribbon? and ?whitewash.?

To screen or not to screen

One hotly debated topic surrounds the benefit of breast cancer screening. In focusing on early detection as prevention, the Susan G. Komen foundation has been criticized for overselling mammograms and under-representing the risks.

Writing in the British Medical Journal in August this year, Dr. Steven Woloshin and Dr. Lisa Schwartz argued that the survival statistics used in advertising campaigns by the foundation were unreliable and made screening appear more beneficial than it actually was. According to them, ?For every life saved by mammography, around two to ten women are overdiagnosed.?

Some say screening tends to identify tumor types that are indolent and cause no harm. Before the BMJ report, a study in the New England Journal of Medicine in 2010 found that while screening mammograms saved lives, there was five to fifteen times the number of women who were unnecessarily diagnosed and treated for cancers that turned out to be harmless.

In late October this year, an independent UK panel investigating the benefit of breast cancer screening found that while screening extends lives, it also led to overdiagnosis. Publishing in the medical journal, The Lancet, the panel found that for every breast cancer death prevented, there were three overdiagnosed cases identified and treated.

And just this week, another report in the New England Journal of Medicine by two MDs, Archie Bleyer and H. Gilbert Welch, presented more data collected over three decades in the US. They found evidence for ?substantial overdiagnosis accounting for nearly a third of all newly diagnosed breast cancers, and that screening is having, at best, only a small effect on the rate of death from breast cancer.?

Giving pink some street cred

Another bugbear of critics is how the language of breast cancer campaigns has recently changed to appeal to the younger generation. Some campaigns have veered into risqu? territory with slogans such as ?Feel your Boobies? and ?Save the Ta-Tas,? in the name of standing out from the crowd. Critics have responded with accusations that they do more harm than good by sexualizing the disease.

?It sexually objectifies women, trivializes breast cancer? and uses the objectified woman as window dressing for the profit-making machine,? explains writer Gayle Sulik in an interview with USA Today.

Others feel that such campaigns simply reinforce the image of breasts being a woman?s most prized possessions, which magnifies the psychological pain endured by women who have had mastectomies.

What say the researchers?

A key area that lacks attention from current campaigns is information on the results of breast cancer research. Charities should take the lead in explaining these so the public can begin to understand the nature of this highly complex disease.

Recently, an international consortium of scientists published the most comprehensive analysis yet of breast cancer. Looking at 825 breast tumor samples, they found that the cancers could be divided into four main classes that are better treated as separate diseases to determine the optimal treatment.

As Dr. Matthew Ellis, Chair of Oncology at Washington University and co-leader of the study, explains:

?With this study, we?re one giant step closer to understanding the genetic origins of the four major subtypes of breast cancer. Now, we can investigate which drugs work best for patients based on the genetic profiles of their tumors.?

Clearly, breast cancer comes in many shapes and sizes and no single magic bullet cure can be developed to treat it. In fact, it is more helpful to think of breast cancer as a family of different diseases with their own characteristics, which influence the type of treatment needed.

This is exactly the type of information that needs to be broadcast to update the public about how research is advancing our knowledge of the disease and how to treat it. Better understanding of the disease itself would make expectations easier to manage.

Dr. H. Gilbert Welch, who co-authored the recent NEJM study confirming the trend of overdiagnosis, believes that healthcare providers should focus on treatment options.

?They can look less hard for tiny cancers and pre-cancers and put more effort into differentiating between consequential and inconsequential cancers,? he wrote in a New York Times editorial.

Despite being mired in doubt about their benefit, money raised through breast cancer awareness campaigns that filter through to cancer research has led to improvement in treatments as well as our understanding of the disease.

And so, distractions aside, I still bought a pink ribbon this year.

??

Copyright: Asian Scientist Magazine; Photo: luxury-insider.com
Disclaimer: This article does not necessarily reflect the views of AsianScientist or its staff.

Source: http://www.asianscientist.com/features/breast-cancer-awareness-staying-in-the-pink-of-health-2012/

seattle mariners geraldo rivera supreme court health care joe oliver joba chamberlain new york mega millions jetblue

Need a lot of sleep? An antidote for hypersomnia

ScienceDaily (Nov. 21, 2012) ? Researchers at Emory University School of Medicine have discovered that dozens of adults with an elevated need for sleep have a substance in their cerebrospinal fluid that acts like a sleeping pill.

The results are scheduled for publication online November 21 by the journal Science Translational Medicine.

Some members of this patient population appear to have a distinct, disabling sleep disorder called "primary hypersomnia," which is separate from better-known conditions such as sleep apnea or narcolepsy. They regularly sleep more than 70 hours per week and have difficulties awakening. When awake, they still have reaction times comparable to someone who has been awake all night. Their sleepiness often interferes with work or school attendance, and conventional treatments such as stimulants bring little relief.

"These individuals report feeling as if they're walking around in a fog -- physically, but not mentally awake," says lead author David Rye, MD, PhD, professor of neurology at Emory University School of Medicine and director of research for Emory Healthcare's Program in Sleep. "When encountering excessive sleepiness in a patient, we typically think it's caused by an impairment in the brain's wake systems and treat it with stimulant medications. However, in these patients, the situation is more akin to attempting to drive a car with the parking brake engaged. Our thinking needs to shift from pushing the accelerator harder, to releasing the brake."

In a clinical study with seven patients who remained sleepy despite above-ordinary sleep amounts and treatment with stimulants, Emory researchers showed that treatment with the drug flumazenil can restore alertness, although flumazenil's effectiveness was not uniform for all seven. Alertness was gauged through the psychomotor vigilance test, a measurement of reaction time.

Flumazenil is usually used in cases of overdose of benzodiazepines, a widely used class of anesthetics and sedatives such as diazepam (Valium) and zolpidem (Ambien). Evidence in the paper suggests that the sleep-inducing substance in patients' cerebrospinal fluid is not a benzodiazepine drug, even though flumazenil counteracts it. Identifying the mysterious "somnogen," which appears to be produced by the body, could give scientists greater insight into how our brains regulate states of consciousness such as alertness and sleep.

"Primary hypersomnias are disabling and poorly understood. This study represents a breakthrough in determining a cause for these disorders and devising a rational approach to therapy," says Merrill Mitler, PhD, a program director at the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health." Further research is required to determine whether or not the results apply to the majority of patients."

The team of researchers involved in this effort includes Rye; Andrew Jenkins, PhD, Emory assistant professor of anesthesiology; and Kathy Parker, PhD, RN, FAAN, previously at Emory and now at University of Rochester Medical Center.

The paper describes how samples of patients' cerebrospinal fluid (CSF) contain a substance that enhances the effects of the brain chemical GABA (gamma-amino butyric acid). GABA is one of the main inhibitory chemicals of the nervous system -- alcohol, barbituates and benzodiazepines all enhance the effects of GABA. In the laboratory, the size of the effect on GABA receptor function is more than twice as large in the hyper-sleepy patients, on average, than in control samples.

"In some of the more severely affected patients, we estimated the magnitude of the GABA-enhancing effect as nearly equivalent to that expected for someone receiving sedation for outpatient colonoscopy," Rye says. "This is a level of impaired consciousness that many subjects had to combat on almost a daily basis in order to live their usual lives."

The ICSD-2 (International Classification of Sleep Disorders) terms this disorder "primary hypersomnia" and the proposed DSM-V describes it as "major hypersomnolence disorder." Its prevalence is unclear. The Emory team's findings could potentially provide a biological definition and a treatment for an under-recognized sleep disorder.

The patients in the group examined in the paper have received a variety of diagnoses, including idiopathic hypersomnia and narcolepsy without cataplexy. Cataplexy is a sudden loss of muscle tone, sometimes triggered by surprise or strong emotion, characteristic to narcolepsy. Other members of the group are simply considered "long sleepers" (more than 10 hours per day).

In addition, the identity of the GABA-enhancing substance is not yet known, although Rye and Jenkins are devising strategies to pin it down. Based on its size and sensitivity to certain enzymes, it could be a peptide, similar to but not the same as the hormones oxytocin or hypocretin. Jenkins and his colleagues have shown that the sleep-inducing substance can act on GABA receptors that are not sensitive to benzodiazepines.

"Previous studies with flumazenil indicate that it does not have a wake-promoting effect on most people, so its ability to normalize vigilance in this subpopulation of extremely sleepy patients appears genuinely novel," Rye says.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Emory University, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. D. B. Rye, D. L. Bliwise, K. Parker, L. M. Trotti, P. Saini, J. Fairley, A. Freeman, P. S. Garcia, M. J. Owens, J. C. Ritchie, A. Jenkins. Modulation of Vigilance in the Primary Hypersomnias by Endogenous Enhancement of GABAA Receptors. Science Translational Medicine, 2012; 4 (161): 161ra151 DOI: 10.1126/scitranslmed.3004685

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/rJTqOHmbUEA/121121145613.htm

US weekly amelia earhart Sally Ride Ichiro minka kelly James Holmes court Rupert Sanders

What To Do After A Los Angeles Car Accident | Personal Injury ...


No matter how big or small, car accidents in Los Angeles can be stressful and scary. The adrenaline rush of preparing to hit or be hit, or the surge of emotions that rush through you after you are hit can leave even the most stoic person a little shaken up. Once an auto accident victims determines that he and his loved ones are safe, the fear associated with the financial costs of a car accident come into play. The long insurance battle that may or may not result in you receiving the money you deserve? The medical bills associated with whiplash or other car accident injuries? These fears can prevent many Los Angelenos from taking the legal action they need in order to best protect themselves.

Many Los Angeles car accident victims are overwhelmed by the idea of suing for personal injury damages because they believe that such legal action is difficult and costly to pursue. However, at the Trial Law Offices of Bradley I. Kramer, MD, Esq. we offer a free consultation about your case and will be honest with you from the beginning about how much, if any, in damages you might be able to recover. ?Additionally, knowing the basics of how to care of yourself or a loved one after a car accident in Los Angeles, including the fundamentals of recovering money for payments to receive compensation from the liable parties, will make the post-Los Angeles car accident process a bit easier.

Involved in a Los Angeles car accident? Here are a few dos and don?ts to consider before and while claiming compensation for injuries:

1. Get Medical Assistance ? Immediately after the accident, seek medical attention. Even if you do not believe that you or your loved ones were injured, some car accident injuries show up days later. ?By seeking out medical help, you can be assured that your injuries, if any, will be treated and properly documented. That being said, it is wise to keep all medical records, receipts, and prescriptions given by the attending physician or nurse.

2. Take Pictures ? Los Angeles car accident victims are advised to take photographs of the accident scene and injuries. With the availability of smart phones and other camera phones, taking pictures is much easier. As an experienced Los Angeles car accident lawyer can attest, photos can serve as strong evidence during a claim for financial damages. Photos can help you strengthen your claim leading to potentially more compensation from the liable party.

3. Contact a Personal Injury Lawyer ? car accident victims are advised to contact a personal injury attorney as soon as possible. A Los Angeles car accident attorney can analyze your potential case to see if you can properly pursue your claim. Additionally, the right lawyer can help you deal with insurance companies, ensuring that you receive sufficient and just compensation. Also, there is a statute of limitations in California that says you cannot bring a lawsuit after a certain period of time, so do not delay in reaching out to a lawyer.

4. Let Your Lawyer Talk to Insurance ? Do not attempt to negotiate with the insurance company by yourself. Not only can it be a frustrating and time consuming experience, you want the assistance of a skilled Los Angeles car accident lawyer to make sure you receive the money you deserve.

5. Do Not Contact the Third Party ? Instead of working out a deal with the liable party, the driver who hit you, let your personal injury lawyer negotiate on your behalf. You can only sue for the same claim once, and you want to make sure you do it right the first time.

California law protects car accident victims. If you were injured in a car accident in Los Angeles, you have the legal right to sue for personal injury damages. This means that you may be entitled to compensatory damages, which includes payments for loss of income, hospitalization and medication expenses, pain and suffering damages, and others.

If you or a loved one has been injured in a Los Angeles car accident and are suffering physically and financially because of someone else?s negligence (such as texting and driving or drinking and driving), contact an experienced?Los Angeles car accident lawyer?today. You might be able to recover money for your injuries, including?compensatory damages. The law is on your side and so are the experienced accident lawyers at The Trial Law Offices of Bradley I. Kramer, MD, Esq.

?

Categories: Blog, Car Accident, Personal Injury

User1

Disclaimer: The information contained in this Weblog (Blog) is provided for informational purposes only, and should not be construed as legal advice on any subject matter. No recipients of content from this site, clients or otherwise, should act or refrain from acting on the basis of any content included in the site without seeking the appropriate legal or other professional advice on the particular facts and circumstances at issue from an attorney licensed in the recipient's state. The content of this Weblog (Blog) contains general information and may not reflect current legal developments, verdicts or settlements. The Trial Law Offices Of Bradley I. Kramer expressly disclaim all liability in respect to actions taken or not taken based on any or all the contents of this Weblog (Blog).

Source: http://www.biklaw.com/what-to-do-after-a-los-angeles-car-accident/

multiple sclerosis falling skies rodney king Webb Simpson Fathers Day Quotes Stevie J mothers day 2012

Wednesday, 21 November 2012

Funny. And Fascinating. - Randy Gage

JV

Yesterday I recorded a special interview with Dr. Joe Vitale on some of the topics and lessons in the Risky Is the New Safe book.? Now if you know Joe, he?s a brilliant guy, and really can ask some searching questions.? So the energy was electric as we explored some of the breathtaking opportunities that will become available to humankind over the next decade or so.?

Of course we talked about cloning, genetic engineering, mobile apps, asteroid mining, ocean floor real estate, social media, the cloud and other topics in the book.? By the time I got to artificial intelligence, Joe couldn?t contain himself any longer.? He practically shrieked, ?How do you THINK this way!? You?re a genius.? But how do you get to THINK like this??

And that is a fascinating question.? One that may offer some revealing insights into prosperity?

I responded that perhaps it was all the drugs I did on the 70?s, or it could be that aliens left me in a basket on my mother?s doorstep.? Either possibility seemed equally plausible to me, but Joe had an even better idea?

?I think I figured it out,? he said ?It?s because you were kicked out of school!?? And that?s leads us down an intriguing line of inquiry.? Because when I really reflect on what he?s suggesting, it makes a lot of sense.

Because I had to take responsibility and create my own curriculum of education, no one told me what to think.? And that allowed me to discover how to think.? Instead of being told what facts to memorize, I was forced to be curious, to inquire, to question things.? I didn?t learn to pass a test; I learned to learn.? So I think Joe may be right.

What do YOU think?

-RG

Source: http://www.randygage.com/blog/funny-and-fascinating/

super tuesday epidemiology total eclipse of the heart jionni lavalle earthquake san francisco donald payne elizabeth berkley

Chikwanda clarifies rounding-off figures in budget | Times of Zambia

Chikwanda

By CHILA NAMAIKO? -

FINANCE Minister Alexander Chikwanda, has said rounding-off figures in the proposed 2013 national Budget is not a new principle as it has been applied in the past.

Mr Chikwanda said the rounding-off of figures was a common practice for financial recording purposes world-wide which should not hold back approval of the Budget.

Last week, MPs argued during debate on estimates of revenue and expenditure for the Judiciary and Foreign Affairs Ministry that there were some errors on decimalised figures, prompting Speaker of the National Assembly, Patrick Matibini, to order Mr Chikwanda to issue a ministerial statement on the matter.

But Mr Chikwanda explained in his ministerial statement yesterday in Parliament that it was not the first time the rounding-off method was used as the same principle had been applied in all budgets approved by the House between 2004 and 2012.

?Therefore, all ngwee figures in Yellow Books have always been rounded-off to the nearest Kwacha since 2004, when the first Activity-Based Budgeting (ABB) format Yellow Book was presented to this House,? he said.

The minister laid on the table, extracts of similarly rounded-off figures from the budgets of the last eight years and the 2009, 2010 and 2011 Yellow Books which were debated and approved by the House.

?Mr Chairman, in view of the fore-going and in the interests of progress, I have proposed necessary amendments on all areas of the 2013 Budget, yet to be debated, that are affected by the rounding-off principle, ? he said.

The minister has since assured the House that the use of the rounding-off principle would not alter the total 2013 national Budget at all.

The minister reiterated that the figures in the Budget database were captured up to the level of ngwee.

He, however said the ABB was first introduced in 2003, and Government consulted with the legislature through the Committee on Estimates, regarding the format for presenting the Yellow Book to the National Assembly.

Mr Chikwanda told the House that the Committee on Estimates approved the ABB format for the Yellow Book which included the rounding-off of the ngwee figures to the nearest Kwacha.

In going forward on rebasing of the Kwacha, Mr Chikwanda said the Treasury would be going for consultation with members of the House on the format of the future Yellow Books which was likely to be presented in the House with ngwee figures.

?I hope that the honourable members will rise to the occasion and provide the necessary guidance on an appropriate format that will not cause any misunderstanding amongst ourselves in the House,? Mr Chikwanda said.

He said members should move forward to address various intractable problems that were common afflictions of the long suffering people.

He said page 143 of the 2011 Yellow Book under Home Affairs Ministry on the programme total for programme 02-General Administration, was rounded-off.

This was also the case on page 131 of the 2010 Yellow Book under Ministry of Energy and Water Development and on page 457 of the 2009 Yellow Book under the Ministry of Community Development and Social Services, among others.

He said the extracts also included rounded-off figures under the ministries of Agriculture and Local Government and Housing during the years when MMD Vubwi MP, Eustackio Kazonga who had 30 years experience as a statistician, was the minister responsible.

Mr Chikwanda said Dr Kazonga fervently presented and defended such budget figures on the floor of the House although today, he could not but opted to understand the well-established mathematical principles on rounding-off of decimalised figures.

Meanwhile, the Re-Domination of Currency Bill has passed the Committee Stage in the House without any amendments and would go through Third Reading today

?

?

Source: http://www.times.co.zm/?p=20469

andy williams andy williams Lady Gaga New Girl Avalanna Gigi Chao Jimmy Hoffa

Tuesday, 20 November 2012

A CUP OF JO: Paris elopement

This is lovely, but there seems to be a lot of elopement 'porn' out there these days...and I can't help but wonder if it defeats the purpose of eloping. I mean--you have what's supposed to be this private wedding ceremony, but it's recorded and then it's posted on the internet for the whole world to see and fawn over. Don't get me wrong, this video is great and if it were my wedding I'd cherish it forever and want to share it...but it's also so slick, which gives the whole thing a performative vibe. Like a regular wedding, I suppose. I love weddings, loved my own, and I love watching these videos and the photos you've been posting. But I also love the idea of a old fashioned elopement, where the ceremony is truly, really, deeply intimate and private. This kind of feels like a music video of an elopement.

ReplyDelete

Source: http://joannagoddard.blogspot.com/2012/11/paris-elopement.html

super bowl recipes denver weather planned parenthood what time does the superbowl start kobayashi margaret sanger paul george

The Gaza confrontation ? a major test case for the ?Arab Spring? (Powerlineblog)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, RSS Feeds and Widgets via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/264055320?client_source=feed&format=rss

Tom Kenny Long Island Medium Alfonso Ribeiro cbs sports adam sandler cbs College Football Scoreboard